Claude Opus 4.5 vs Llama-3.3 Nemotron Super 49B

Claude Opus 4.5

Anthropic

Claude Opus 4.5, released by Anthropic in November 2025, is a large language model from the Claude 4.5 family built for demanding reasoning tasks, advanced code generation, and complex agentic workflows. It features a 200K token context window, 64K maximum output tokens, native image understanding, and extended thinking with configurable effort levels. Opus 4.5 targets deep analytical work, multi-step tool orchestration, and applications requiring sustained reasoning across long, complex tasks.

Llama-3.3 Nemotron Super 49B

NVIDIA

Llama-3.3-Nemotron-Super-49B-v1 is a 49-billion-parameter model from NVIDIA, fine-tuned from Meta's Llama 3.3 using NVIDIA's Nemotron post-training pipeline that combines supervised fine-tuning with reinforcement learning to enhance reasoning, instruction alignment, and complex problem-solving. The Super tier in the Nemotron family represents a mid-range capability level — positioned above the Nano series and below the Ultra 253B flagship — offering a balance between high-quality outputs and manageable inference infrastructure requirements. Released open-weight on HuggingFace with NVIDIA NIM support, it targets teams with multi-GPU setups who need strong reasoning capability without the scale of the Ultra model.