InternS1 vs Llama-3.1 Nemotron Ultra 253B

Shanghai AI Lab

InternS1, released by Shanghai AI Laboratory at WAIC 2025 on July 26, 2025, is a multimodal scientific reasoning large language model designed for advanced problem-solving across mathematics, physics, chemistry, and related domains. It supports text, image, and potentially other scientific data formats as input, and demonstrated strong performance on competition-level scientific benchmarks. InternS1 targets open-source scientific research, STEM education, and applications requiring deep domain reasoning across natural science disciplines.

Llama-3.1 Nemotron Ultra 253B

NVIDIA

Llama-3.1-Nemotron-Ultra-253B-v1 is a 253-billion-parameter model from NVIDIA, derived from Meta's Llama 3.1 405B using neural architecture search (NAS) compression combined with NVIDIA's Nemotron post-training pipeline, which recovers and exceeds the base model's capability after structural compression. Released in April 2025, it supports toggling between a standard instruction mode and an extended reasoning mode via system prompt, allowing the same model to handle both rapid responses and deliberate chain-of-thought tasks. It is the flagship of the Nemotron family, available open-weight on HuggingFace and through NVIDIA NIM for enterprise inference.