InternS1 vs Llama-3.3 Nemotron Super 49B

Shanghai AI Lab

InternS1, released by Shanghai AI Laboratory at WAIC 2025 on July 26, 2025, is a multimodal scientific reasoning large language model designed for advanced problem-solving across mathematics, physics, chemistry, and related domains. It supports text, image, and potentially other scientific data formats as input, and demonstrated strong performance on competition-level scientific benchmarks. InternS1 targets open-source scientific research, STEM education, and applications requiring deep domain reasoning across natural science disciplines.

Llama-3.3 Nemotron Super 49B

NVIDIA

Llama-3.3-Nemotron-Super-49B-v1 is a 49-billion-parameter model from NVIDIA, fine-tuned from Meta's Llama 3.3 using NVIDIA's Nemotron post-training pipeline that combines supervised fine-tuning with reinforcement learning to enhance reasoning, instruction alignment, and complex problem-solving. The Super tier in the Nemotron family represents a mid-range capability level — positioned above the Nano series and below the Ultra 253B flagship — offering a balance between high-quality outputs and manageable inference infrastructure requirements. Released open-weight on HuggingFace with NVIDIA NIM support, it targets teams with multi-GPU setups who need strong reasoning capability without the scale of the Ultra model.